Your total trip with all stops is around 830 miles / 1330 km, taking roughly 13 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between Mississippi and Iowa.
Start from Mississippi (MS).
Memphis, Tennessee is stopping point #1 after driving about 180 miles (280 km) or 3 hours.
Saint Louis, Missouri is stopping point #2 after driving about 280 miles (460 km) or 4 hours. Your total trip so far is about 460 miles or 740 km over roughly 7 hours of driving.
Iowa City, Iowa is stopping point #3 after driving about 260 miles (420 km) or 4 hours. Your total trip so far is about 720 miles or 1160 km over roughly 11 hours of driving.
Finally, Iowa (IA) is your destination after driving about 110 miles (170 km) or 1.5 hours. Your total trip with all stops is around 830 miles or 1330 km, taking roughly 13 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.